Prebiotics and Pigmentation: Illuminyl™ 388 and the Power of EGCG

From Tea to Skincare: Illuminyl™ 388 and the Future of Brightening

Imagine walking into a lab where scientists are deep in thought, pondering how to harness one of nature’s most potent molecules. They’re grappling with a challenge—how to make the extraordinary properties of green tea’s hero molecule, EGCG, useful for skincare. It’s a molecule revered for its antioxidant and anti-inflammatory benefits but problematic for cosmetic use due to its poor solubility and rapid degradation when exposed to air.

Now, picture this: a solution emerges, one that allows EGCG to shine in the world of skincare. Enter Illuminyl™ 388, a monoglucoside of EGCG developed by Givaudan Active Beauty. It’s more than just a molecule—it’s a bridge between traditional wisdom and cutting-edge biotechnology.

The Science Behind the Glow

tea camellia sinensis the upper leaves on the bushes. green tea leaves on a branch.

Green tea, especially in its epigallocatechin gallate (EGCG) form, has been hailed for centuries in traditional Asian medicine. Yet, for all its potential, EGCG has been a formulators’ nightmare. It’s unstable, degrades quickly, and resists dissolving in water—a trifecta of problems when you want to integrate it into cosmetics.

But science loves a challenge, and this is where biotechnology steps in. Through a precise biocatalysis process, Givaudan Active Beauty cracked the code: they grafted a glucose molecule onto EGCG, creating a more stable and soluble version. This breakthrough, Illuminyl™ 388, amplifies EGCG’s bioavailability by 90%, allowing it to penetrate deeper into the skin, providing all the benefits without the formulation headaches.

illuminyl 388 brightening activity egcg

The All-in-One Solution for Skin Radiance and Brightening

lluminyl™ 388 doesn’t just offer antioxidant protection; it revolutionizes how we think about skin brightening and pigmentation correction. Through a multi-targeted approach, this molecule addresses the four main stages of pigmentation: melanogenesis, tyrosinase activity, melanosome maturation, and melanin transfer. In simpler terms, it works at every level to ensure that your skin can achieve a more even tone and brighter radiance.

illuminyl 388 mode of action

Clinical trials tell the story best. In just two weeks, volunteers with various skin types experienced significant improvements in skin luminosity, radiance, and tone homogeneity. In fact, compared to Vitamin C—a longtime benchmark in skincare brightening—Illuminyl™ 388 outperformed it by a factor of 3.3 when it came to improving skin radiance. And the benefits don’t stop there.

illuminyl 388 clinical efficacy

Beyond Brightening: The Prebiotic Effect

We now know that skin health is deeply intertwined with the microbiome—the diverse ecosystem of bacteria living on the surface of your skin. Illuminyl™ 388 also supports this microbial community. It boosts the growth of beneficial bacteria, such as Lactobacillus acidophilus, which produces a niacin-derivative called trigonelline. This derivative enhances the molecule’s brightening effect by reducing tyrosinase activity, which in turn decreases melanin production, delivering a glow that goes beyond the surface.

illuminyl 388 prebiotic activity

Illuminyl™ 388 in Action

From the lab to your skin, Illuminyl™ 388 stands out as a skincare ingredient that blends traditional wisdom with the latest in biotech innovation. It’s water-soluble, easy to formulate, and clinically proven to deliver visible results in record time—whether it’s reducing dark spots or evening out skin tone.

For brands and formulators, this means access to an ingredient that is as effective as it is efficient. It offers the power of EGCG without the stability and solubility challenges, making it a game-changer for brightening creams, anti-aging serums, and more.

In the end, Illuminyl™ 388 is a story of how science took an ancient ingredient and made it modern, versatile, and powerful—so that, like the green tea plant itself, its benefits can endure for generations.

Illuminyl™ 388 Leaflet
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