How Stem Cell Technology is Transforming Skin Regeneration

Akosky™ Apium: A Natural Solution to Rebuild Skin Architecture and Smooth Out Stretch Marks

In skincare, the pursuit of rejuvenation often draws inspiration from nature. Akosky™ Apium, derived from celery stem cells, embodies this philosophy, combining advanced biotechnology with the power of natural plant compounds to target two common skin concerns: wrinkles and stretch marks. Let’s explore how this innovative active works, its origins, production, and the scientific backing behind its efficacy.

akosky apium technology

Akosky™ Apium is sourced from Apium graveolens, better known as celery. Through a controlled and eco-sustainable process, celery stem cells are grown in a lab environment. This prevents environmental depletion while ensuring the production of highly active compounds like polyphenols and peptides. Celery stem cells, undifferentiated plant cells, are cultivated using advanced biotechnology to maximize their regenerative potential​.

The production process begins with callus formation from the celery plant, followed by liquid culture to scale up the active ingredients. These are extracted, lyophilized into a pure powder, and combined with glycerin, creating a hydrosoluble active that is easily incorporated into skincare formulations​.

akosky apium production process

How It Works: Mechanism of Action

The foundation of Akosky™ Apium lies in its unique ability to regenerate and fortify the skin’s extracellular matrix (ECM). The ECM is essential for maintaining skin’s structure, elasticity, and overall health. With aging, exposure to environmental stressors, or rapid changes in skin such as those seen during pregnancy or weight fluctuations, the ECM’s integrity weakens, leading to a visible loss of firmness, the appearance of wrinkles, and the development of stretch marks.

To counteract these effects, Akosky™ Apium stimulates the production of key proteins—collagen, fibronectin, and SPARC—that are crucial for maintaining and restoring the ECM. This regenerative approach, rooted in plant-based bioactive compounds, helps rebuild the skin’s density and promotes tissue repair.

Let’s delve into how Akosky™ Apium works specifically in reducing wrinkles and diminishing stretch marks.

Wrinkle Reduction

Wrinkles form as collagen in the skin breaks down due to aging, environmental stress, and loss of skin density. Akosky™ Apium directly targets this process by boosting the production of two key types of collagen—ProCollagen I and III. In vitro studies show that Akosky™ Apium increases ProCollagen I by 34% and ProCollagen III by 23%, improving skin’s structural support and firmness​.

akosky apium mechanism of action wrinkles reduction

Additionally, the active upregulates SPARC, a protein essential for collagen fiber assembly. SPARC helps organize the collagen structure within the extracellular matrix (ECM), making the skin denser and more resilient to wrinkles. Clinical studies back this up: after two months of applying a cream with 2% Akosky™ Apium, participants saw a 27% increase in skin density and a 5% increase in skin thickness.

akosky apium skin density and thickness increase

This improved collagen structure leads to visible reductions in wrinkles. Clinical trials using Visia image analysis showed a 25% reduction in wrinkle volume, a 23% reduction in the number of wrinkles, and a 19% reduction in skin roughness, highlighting how Akosky™ Apium smooths and rejuvenates the skin​.

akosky apium wrinkles visibly reduced
Stretch Mark Reduction

Stretch marks occur when skin is rapidly stretched—often during pregnancy or weight changes—leading to disorganized collagen fibers. Akosky™ Apium helps reorganize these fibers by promoting collagen production and stimulating SPARC protein expression. This leads to more organized collagen in and around stretch marks, enhancing the skin’s ability to repair itself​.

akosky apium mechanism of action stretch marks reduction

In a clinical study involving 40 women aged 18-50, participants applied a 2% Akosky™ Apium body cream for two months. The results were significant: stretch marks were visibly reduced by 22%, with a 19% reduction in the color contrast between stretch marks and surrounding skin. The skin became smoother, with an 80% improvement in perceived stretch mark size​.

akosky apium stretch marks visibly reduced

Clinical Evidence: What the Studies Show

Wrinkle Reduction

In a clinical trial with 20 participants (aged 25-60), Akosky™ Apium at 2% concentration was applied daily for two months.

akosky apium clinical test wrinkle reduction
  • A 27% increase in skin density, assessed via high-frequency ultrasound
  • A 5% increase in skin thickness
  • A 25% reduction in wrinkle volume
  • A 19% reduction in skin roughness
Stretch Mark Reduction

A separate trial with 40 women (aged 18-50) focused on stretch marks. Akosky™ Apium at 2% concentration was applied daily for two months.

akosky apium clinical test stretch mark reduction
  • A 22% reduction in stretch mark visibility
  • A 19% reduction in the color contrast of stretch marks, improving the overall appearance of the skin

Natural Innovation for Comprehensive Skin Rejuvenation

Akosky™ Apium stands out in the skincare world by leveraging the regenerative power of celery stem cells. Through its dual-action approach—stimulating collagen production and improving collagen organization—Akosky™ Apium tackles both wrinkles and stretch marks. Supported by clinical data, it provides a scientifically proven, sustainable option for rejuvenating and re-densifying the skin.

Whether targeting signs of aging or reducing stretch marks, Akosky™ Apium offers a powerful, natural-based solution backed by innovation and rigorous clinical research.

Akosky™ Apium Flyer
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