Givaudan Active Beauty launches PrimalHyal™ UltraReverse

Tackling aging at its source for skin longevity

Givaudan Active Beauty is delighted to unveil PrimalHyal™ UltraReverse – the smallest and most sustainable hyaluronic acid ever developed. This active ingredient has the unique ability to penetrate skin cells and act at the DNA level, effectively addressing most of the primary hallmarks of aging. By tackling aging at its root, PrimalHyal™ UltraReverse is set to redefine the ‘well-aging’ experience.

PrimalHyal™ UltraReverse, the intracellular hyaluronic acid, targets four of the five primary hallmarks of aging:

Epigenetic control

Restoring DNA methylation processes and enhancing sirtuins expression and activity, limiting cryptic transcription.

Genomic instability

Amplifying DNA repair mechanisms for a healthier skin.

Telomeres attrition

Reactivating telomerase expression and activity, protecting the chromosomes integrity.

Loss of proteostasis

Boosting the proteasome activity to ensure optimal cellular function.

giv primalhyal ultrareverse 900x600

By targeting these biological pathways, PrimalHyal™ UltraReverse protects the skin not only from chronological ageing, but also from environmental stressors known as the exposome.

It increases sirtuin 1 by +136% and improves collagen 1 production by +48%, helping to restore skin’s youthfulness. The result?

Visibly younger, healthier skin, with an apparent age reduced by up to six years. It also corrects key signs of aging, including wrinkles and sleep lines while offering improved skin firmness, as demonstrated on a diverse and international panel of volunteers.

“Building on the expertise of PrimalHyal™ 50 Life, strain engineering experts at Alderys have designed PrimalHyal™ UltraReverse, an ultra-low molecular weight hyaluronic acid, lower than 3 kDa, that unlocks new biological benefits. Produced by precision fermentation, its environmental impact is drastically reduced – setting a new benchmark for sustainable, high-performance skincare.”

Romain Reynaud, Research & Development Director

“Longevity has become a key trend in the beauty industry, driven by growing consumer interest in prevention and a holistic approach to skin health. In fact, 84% of people agree that they should embrace their age rather than trying to hide it, underlining the move towards a more authentic perspective on ageing1. Givaudan Active Beauty emphasises that true skincare is not just about appearance, but about longevity, prevention and wellbeing, by offering solutions that preserve the skin’s health capital.”

Mathias Fleury, Head of Category Active ingredients

To learn more about Givaudan Active Beauty new ingredient and its marketing concept, S3D® Reverso, check out their brochure below or connect to uxbeauty.givaudan.com, Givaudan’s digital platform dedicated to cosmetic ingredients.

PrimalHyal™ UltraReverse Leaflet
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