Akosky® Pink Beauty: The Epigenetic Approach to Skin Restoration
DNA is under constant assault from the world around us—UV radiation, pollutants, and even lifestyle factors like diet all take their toll. This ongoing damage leads to the breakdown of cellular function, making skin more susceptible to aging and disease. Enter Akosky® Pink Beauty, a powerful solution by Akott Evolution. Leveraging the principles of epigenetics, Akosky® Pink Beauty targets DNA repair directly, aiming to reduce damage and restore skin health by modulating the way our genes express themselves without altering their underlying sequence.
National Institutes of Health (2023). “A Scientific Illustration of How Epigenetic Mechanisms Can Affect Health“. URL: https://commonfund.nih.gov/epigenomics/figure
Epigenetics involves modifications that change gene activity without altering the DNA sequence. Akosky® Pink Beauty focuses on one of the key mechanisms of epigenetic regulation: histone modification. Histones, the proteins around which DNA is wrapped, undergo chemical changes like acetylation and deacetylation that either condense or relax DNA structure. Akosky® Pink Beauty uses HDAC inhibitors—compounds that reduce histone deacetylation—to facilitate a more open chromatin state, which enhances the natural DNA repair processes.
Unique Extract Origin and Composition
Akosky® Pink Beauty is derived from the sprouted roots of Rose Winter Radish, an ancient species of radish from the Brassicaceae family. Rich in glucosinolates, these radish sprouts contain potent sulfur-based compounds with numerous health benefits. Glucosinolates transform into bioactive molecules like sulforaphane and raphasatin—known for their antioxidative, anti-inflammatory, and DNA-protective activities—through a natural enzymatic process.
The Rose Winter Radish, known for its resilience to environmental stresses, serves as an ideal source for these active compounds. This extract is a sustainable solution, grown under controlled laboratory conditions to prevent environmental depletion, ensuring high-quality material for cosmetic formulations.
A Special Extraction Process
The power of Akosky® Pink Beauty lies in its unique extraction process. Utilizing ultrasonic technology, Akott Evolution has developed a method that yields a rich and complex mixture of active molecules, preserving the integrity of the naturally occurring glucosinolates, flavonoids, and vitamins found in the radish sprouts. The extract is hydrosoluble, allowing for its easy incorporation into various cosmetic formulations.
Mechanism of Action: DNA Protection
The core mechanism behind Akosky® Pink Beauty is its epigenetic modulation of the DNA repair process. Isothiocyanates from the radish sprouts inhibit histone deacetylase (HDAC) activity, allowing for enhanced DNA repair. When the DNA in skin cells is damaged—such as from UV exposure—the HDAC inhibition helps maintain an open chromatin state, promoting rapid self-repair. This process helps protect against cyclobutane pyrimidine dimers (CPDs), which are lesions in the DNA caused by UV radiation.
In Vitro Efficacy: DNA Protection and Repair
In vitro studies on human keratinocytes have demonstrated the efficacy of Akosky® Pink Beauty in reducing DNA damage and enhancing repair. By applying 2% Akosky® Pink Beauty to UV-irradiated cells, researchers observed significant reductions in CPD formation, along with increased DNA repair activity. This ability to activate the skin’s natural repair mechanisms showcases its effectiveness in fighting the visible effects of aging and environmental damage.
Clinical Test: Post-Irradiation Treatment
The power of Akosky® Pink Beauty extends beyond the lab. In a clinical study involving 20 participants, the extract was tested for its ability to mitigate UV-induced skin damage. The participants were UV-irradiated on three areas of their skin: one was left untreated, one received a placebo, and the other was treated with a cream containing 1% Akosky® Pink Beauty. Results showed a marked reduction in erythema (redness) and improved skin barrier function in the treated area compared to both the placebo and untreated sites, highlighting the extract’s efficacy in both DNA repair and reducing inflammation.
Akosky™ Pink Beauty is a versatile ingredient that can be incorporated into a range of skincare products. Its multifunctionality makes it ideal for anti-aging creams, soothing treatments, and sun care formulations. Whether it’s used in a daily moisturizer to delay photoaging or as part of an after-sun lotion to repair UV-induced damage, Akosky™ Pink Beauty is designed to help maintain healthy, radiant skin.
The secret to resilient skin isn’t just about what we put on it—it’s about empowering skin cells to do what they do best. Akosky™ Pink Beauty does just that: it provides the tools for our skin to protect, repair, and rejuvenate itself, using the best of biotechnology and nature.
